منابع مشابه
WT1 mutations in T-ALL.
The molecular mechanisms involved in disease progression and relapse in T-cell acute lymphoblastic leukemia (T-ALL) are poorly understood. We used single nucleotide polymorphism array analysis to analyze paired diagnostic and relapsed T-ALL samples to identify recurrent genetic alterations in T-ALL. This analysis showed that diagnosis and relapsed cases have common genetic alterations, but also...
متن کاملLYMPHOID NEOPLASIA WT1 mutations in T-ALL
Valeria Tosello,1 Marc R. Mansour,2 Kelly Barnes,1 Maddalena Paganin,3 Maria Luisa Sulis,1,4 Sarah Jenkinson,2 Christopher G. Allen,2 Rosemary E. Gale,2 David C. Linch,2 Teresa Palomero,1,5 Pedro Real,1,6 Vundavalli Murty,1 Xiaopan Yao,7 Susan M. Richards,8 Anthony Goldstone,9 Jacob Rowe,10 Giuseppe Basso,3 Peter H. Wiernik,11,12 Elisabeth Paietta,11,12 Rob Pieters,13,14 Martin Horstmann,15,16 ...
متن کاملA monoclonal antibody (WT1) for detecting leukemias of T-cell precursors (T-ALL).
The selectivity of a monoclonal anti-T antibody, designated WT1, has been assessed in a series of 906 leukemias and lymphomas. In acute lymphoblastic leukemias, WT1 reacts comprehensively and selectively with thymic acute lymphoblastic leukemia (ALL) cells in untreated or relapsed patients, thus overriding the extensive antigenic diversity of this cancer and the immaturity of the cell type invo...
متن کاملActivating Notch1 mutations in mouse models of T-ALL.
Recent studies have demonstrated that most patients with T-cell acute lymphocytic leukemia (T-ALL) have activating mutations in NOTCH1. We sought to determine whether these mutations are also acquired in mouse models of T-ALL. We sequenced the heterodimerization domain and the PEST domain of Notch1 in our mouse model of TAL1-induced leukemia and found that 74% of the tumors harbor activating mu...
متن کاملNOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.
Heterodimerization domain (HD) mutations in NOTCH1 induce ligand-independent activation of the receptor and contribute to the pathogenesis of one-third of human T-cell lymphoblastic leukemias (T-ALLs). Here we report a novel class of activating mutations in NOTCH1 leading to aberrant activation of NOTCH1 signaling in T-cell lymphoblasts. These so-called juxtamembrane expansion (JME) alleles con...
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ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2008-12-192039